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Juvekar, A. R.
- Hypoglycemic Activity of Cassia auriculata in Neonatal Streptozotocin-induced Non-insulin Dependent Diabetes Mellitus in Rats
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Journal of Natural Remedies, Vol 6, No 1 (2006), Pagination: 14-18Abstract
Objective: The primary objective of the present research work was to investigate the effect of ethanol and aqueous extract of Cassia auriculata in streptozotocin induced neonatal model of Non-Insulin Dependent Diabetes Mellitus (NIDDM). Methodology: The ethanol extract of whole plant powder of Cassia auriculata was obtained by successive solvent extraction with petroleum ether (60-80°C) and ethanol (95%v/v). The aqueous extract was obtained by boiling plant material in distilled water and concentrated by evaporation. The rats were divided into 4 groups as diabetic treated and two groups maintained as control and diabetic control, each group contained six rats. The ethanol (400mg/kg) and aqueous extract (250mg/kg, 500mg/kg) of the Cassia auriculata administered orally to streptozotocin induced diabetic rats once a day and evaluated for hypoglycemic activity. The blood glucose, triglyceride, HDL cholesterol and total cholesterol were studied in streptozotocin induced neonatal diabetic rat model. Results: Cassia auriculata ethanol extract at dose of 400 mg/kg whereas aqueous extract at doses 250 and 500 mg/kg of their body weight were administered to diabetic rats for 28 days, lead to suppression in elevated glucose, cholesterol and triglycerides levels. The glibenclamide (0.45mg/kg) was used as reference standard. Conclusion: From the results obtained, it can be observed that ethanol and aqueous extract of Cassia auriculata have antidiabetic potential. The findings indicate that the Cassia auricualata possess the hypoglycemic as well as the antihyperlipidemic activity.Keywords
Blood Glucose, Cassia auriculata, Streptozotocin, Flavonoids- Anti-Diarrheal Activity of Methanolic and Aqueous Extracts of Dillenia indica L
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Authors
S. B. Yeshwante
1,
A. R. Juvekar
1,
R. B. Pimprikar
2,
R. T. Kakade
2,
M. Tabrej
2,
M. K. Kale
3,
S. D. Firke
3
Affiliations
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
1 Department of Pharmacology, Institute of Chemical Technology, Matunga, Mumbai- 400019, IN
2 Gangamai College of Pharmacy, Nagaon, Dhule, IN
3 KYDSCT's College of Pharmacy, Sakegaon, Jalgaon, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 140-142Abstract
The methanolic extract of Dillenia indica leaves have been reported to possess anti-inflammatory activity. Inflammatory mediators such as prostaglandins and bradykinins are involved in the pathogenesis of diarrhea. The aim of the present work was to evaluate the anti-diarrheal activity of aqueous and methanolic extracts of Dillenia indica leaves. The anti-diarrheal activity was evaluated using Castor oil induced diarrhea model and different parameters such as onset of diarrhea and total number of feaces for the period of 4 hours. were observed. The results of test group were compared with Vehicle control group using one way ANOVA followed by Dunnett's Test. The results revelaled that both extracts at doses of 200 and 400mg/kg P.O. showed significant (P<0.01) prolongation of onset of diarrhea and significant (P<0.01) reduction in total number of feaces after 2nd hour of treatment while dose of 100mg does not show any activity. From the results it can be concluded that the inhibition of the diarrhea and prolongation of onset might be due to inhibition of inflammatory mediator release and phyto-constituents such as flavonoids and tannins may have also contributed to the anti-diarrheal activity.Keywords
Dillenia indica, Dilleniaceae, Castor Oil, Aqueous and Methanolic Extracts.References
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